기관회원 [로그인]
소속기관에서 받은 아이디, 비밀번호를 입력해 주세요.
개인회원 [로그인]

비회원 구매시 입력하신 핸드폰번호를 입력해 주세요.
본인 인증 후 구매내역을 확인하실 수 있습니다.

회원가입
서지반출
Isolation of Triterpenoids from the Stem Bark of Albizia julibrissin and Their Inhibition Activity on ACAT-1 and ACAT-2
[STEP1]서지반출 형식 선택
파일형식
@
서지도구
SNS
기타
[STEP2]서지반출 정보 선택
  • 제목
  • URL
돌아가기
확인
취소
  • Isolation of Triterpenoids from the Stem Bark of Albizia julibrissin and Their Inhibition Activity on ACAT-1 and ACAT-2
저자명
Baek. Mi-Young,Cho. Jin-Gyeong,Lee. Dae-Young,Ahn. Eun-Mi,Jeong. Tae-Sook,Baek. Nam-In
간행물명
Journal of the Korean Society for Applied Biological Chemistry
권/호정보
2010년|53권 3호|pp.310-315 (6 pages)
발행정보
한국응용생명화학회
파일정보
정기간행물|
PDF텍스트
주제분야
기타
이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
서지반출

기타언어초록

The dried stem bark of Albizia julibrissin was extracted in 70% aqueous EtOH, and concentrated extracts were partitioned with EtOAc, n-BuOH, and $H_2O$, successively. From the EtOAc fraction, three triterpenoids were isolated through repeated silica gel and octadecyl silica gel column chromatography. Based on nuclear magnetic resonance spectrometry (NMR), mass spectrometry, and infrared spectroscopy spectroscopic data, the chemical structures of the compounds were determined to be lupeol (1), betulinic acid (2), and oleanolic acid (3). This was the first report in which compounds 1, 2, and 3 were isolated from the stem bark of A. julibrissin. Since the NMR data for some compounds have been incorrectly or incompletely identified in previous literature, the NMR were revised on the basis of 2-D NMR experiments. Compounds 1, 2, and 3 showed inhibition activity on ACAT-1 with values of $89.3{pm}3.7%$, $61.2{pm}3.4%$, and $52.5{pm}0.7%$, respectively, at a concentration of $50;{mu}g/mL$ and on ACAT-2 with values of $44.3{pm}2.1%$, $55.5{pm}0.3%$, and $22.0{pm}2.6%$, respectively, at a concentration $50;{mu}g/mL$.