This paper presents an investigation into the MQL (minimum quantity lubrication) and wet turning processes of AISI 1045 work material with the objective of suggesting the experimental model in order to predict the cutting force and surface roughness, to select the optimal cutting parameters, and to analyze the effects of cutting parameters on machinability. Fractional factorial design and central composite design were used for the experiment plan. Cutting force and surface roughness according to cutting parameters were measured through the external cylindrical turning based on the experiment plan. The measured data were analyzed by regression analysis and verification experiments were conducted to confirm the results. From the experimental results and regression analysis, this research project suggested the experimental equations, proposed the optimal cutting parameters, and analyzed the effects of cutting parameters on surface roughness and cutting force in the MQL and wet turning processes.