In this paper, novel approximated closed-form expressions of the SER(Symbol Error Rate) and BER(Bit Error Rate) are presented for the multi-input multi-output space-time block coding(MIMO-STBC) system employing two transmit and N receive antenna(s) in Rayleigh fading channels. Assuming a zero-forcing equalizer and a single-symbol maximum-likelihood (ML) decoder, the formulas are derived for the SER and BER, and then their approximated counterparts are also derived. In the derivation of the approximated expressions, acurve-fitting model is adopted that can eliminate the integral operators in the exact expressions.