Purpose: The aim of this study was to identify the correlation among job stress, drinking, and smoking of local government staff. Methods: The participants of this study were 205 government staffs working in a local government office. The data were collected by self-report using questionnaires from March 2 to April 30, 2009. The data were analyzed using t-test, Chisquare test, ANOVA, and Man-Whitney test. Results: Physical stress was the highest in job stress components. Majority of the participants (96%) had drinking experiences more than once per month. 25.4% of respondents reported they drank more than 10 glasses each time. Smoking was habitual in 36.6% of the subjects and 28% of subjects had participation in a smoking cessation program. Respondents who reported high job stress had a longer history of smoking. Conclusions: Job stress was highly associated with drinking and smoking. Stress control programs and smoking and alcohol cessation/moderation programs could be beneficial for the health of government staffs.