The large-scale disasters occur to unexpected accidents such as natural disasters(earthquake, typhoon, tsunami, etc.), and human-caused accidents(fire, collapse, terror etc.). Rescue teams perform rescue activities to save many lives in large-scale disaster area. The main purpose of this study is to compose a optimal routing planning for rescue of multiple victims in disaster area. A realistic routing planning with rescue limit time which considers rehabilitation and reconstruction will be suggested in this study. A mathematical programming model and a hybrid genetic algorithm will be suggested to minimize the total spending time. By comparing the result, the suggested algorithm gives a better solution than existing algorithms.