This paper presents the optimization process of liquid desiccant cooling system using LiCl aqueous solution as a working fluid. Operating conditions(mass flow rate, conditioner outlet concentration, difference concentration) and design factors for heat exchangers(difference temperature of the district heating water, leaving temperature difference of the conditioner, leaving temperature difference of the regenerator, air temperature difference of the conditioner, air temperature difference of the regenerator) were optimized by response surface method. As a result, we obtained the 7.297 kW of cooling capacity and 0.788 of COP at optimized condition. Effect of difference temperature of hot water on system performances was also examined. As difference temperature of the district heating water increases, the cooling capacity increases and COP decreases.