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In vitro and Mechanism Study of Poly(ethylene-co-vinyl acetate)-Based Implant for Sustained Release of Vitamin B12
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  • In vitro and Mechanism Study of Poly(ethylene-co-vinyl acetate)-Based Implant for Sustained Release of Vitamin B12
저자명
Zhang. Chi,Easteal. Allan J.,Edmonds. Nei R.,Liang. Genhai,Razzak. Majid,Leech. Wayne
간행물명
Macromolecular research
권/호정보
2010년|18권 7호|pp.653-659 (7 pages)
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한국고분자학회
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

A polymer-vitamin B12 implant system has been developed to overcome the disadvantages of traditional vitamin B12 administration to sheep. The ethylene/vinyl acetate (EVAc) copolymer was pre-blended with crystalline vitamin B12. The blends were then extruded at $100^{circ}C$ at a constant pressure and rate using a piston extruder to form a polymer-vitamin B12 composite cord. The final implant was a cylinder 2 mm in diameter and 4 mm in length. Determination of the rate of vitamin B12 release from the implant into a pH7.4 phosphate buffer at $37^{circ}C$ showed that the release rate was strongly dependent on the feed concentration, size and shape of vitamin B12 crystals. The well-known Korsmeyer-Peppas exponential equation was applied to and the release mechanism was found to be a typical anomalous transport mechanism with a strong diffusion-controlled feature between pure diffusion-controlled and Case-II transport mechanisms because the n values obtained were between 0.45 and 0.51 for most polymer-vitamin B12 cylindrical implant systems.