Numerical predictions of a fully developed turbulent flow through a square duct ($30mm{ imes}30mm$) with twisted tape inserts and with twisted tape plus interrupted ribs are respectively conducted to investigate regionally averaged heat transfer and flow patterns. A rib height-to-channel hydraulic diameter(e/$D_h$) of 0.067 and a lengthto-hydraulic diameter(L/$D_h$) of 30 are considered at Reynolds number ranging 8,900 to 29,000. The interrupted ribs are axially arranged on the bottom wall. The twisted tape is 0.1 mm thick carbon steel sheet with diameter of 28 mm, length of 900 mm, and 2.5 turns. Each wall of the square channel is composed of isolated aluminum sections. Two heating conditions are investigated for test channels with twisted tape inserts and rib turbulators: (1) electric heat uniformly applied to four side walls of the square duct, and (2) electric heat uniformly applied to two opposite walls of the square channel. The results show that uneven surface heating enhances the heat transfer coefficient over uniform heating conditions, and significant improvements can be achieved with twisted tape inserts plus interrupted ribs.