Masonry infill walls are frequently used as interior partitions and exterior walls in low- or middle- rise RC buildings. In the design and assessment of buildings, the infill walls are usually treated as non-structural elements and they are ignored in analytical models because they are assumed to be beneficial to the structural responses. Therefore, their influences on the structural response are ignored. In the case of buildings constructed in the USA in highly seismic regions, infill walls have a lower strength and stiffness than the boundary frames or they are separated from the boundary frames. Thus, the previously mentioned assumptions may be reasonable. However, these systems are not usually employed in most other countries. Therefore, the differences in the seismic behaviors of RC buildings with/without masonry infill walls, which are ignored in structural design, need to be investigated. In this study, structural analyses were performed for a masonry infilled low-rise RC moment-resisting frame. The infill walls were modeled as equivalent diagonal struts. The seismic behaviors of the RC moment-resisting frame with/without masonry infill walls were evaluated. From the analytical results, masonry infill walls can increase the global strength and stiffness of a structure. Consequently, the interstory drift ratio will decrease but seismic forces applied to the structure will increase more than the design seismic load because the natural period of the structure decreases. Partial damage of the infill walls by the floor causes vertical irregularity of the strength and stiffness.