Seismic fragility curves of structures represent the probability of exceeding the prescribed structural damage state for a given various levels of ground motion intensity, such as peak ground acceleration (PGA). This means that seismic fragility curves are essential to the evaluation of structural seismic performance and assessments of risk. Most of existing studies have not considered the near- and far-fault earthquake effect on the seismic fragility curves. In order to evaluate the effect of near- and far-fault earthquakes, seismic fragility curves for PSC box girder bridges subjected to near- and far-fault earthquakes are calculated and compared. The seismic fragility curves are strongly dependent on the earthquake characteristics such as fault distance. This paper suggests that the effect of near- and far-fault earthquakes on seismic fragility curves of PSC box girder bridge structure should be considered.