Recently, roll-to-roll printers are being developed actively by various research teams such as research institutes, universities and companies for the application of printed electronics. The printing methods that are widely used in the roll-to-roll printing equipments are gravure, gravure and flexo, which depend on the inks used and electronic devices produced. In general, a single printing unit of roll-to-roll printing equipment adopts only one printing method and this method is not changeable, which limits the application fields of the developed printing equipments. In this paper, the roll-to-roll printer, in which the printing unit has the novel design concept, is described.