Agricultural automation has become more and more important by environmental change. The automation demands the highest technology due to the ever changing various conditions in agriculture system. In the paper, semi-autonomous pesticide spray robot system has been developed for rose farming in the glass house. The robot is in autonomous mode during pesticide spraying process driven on pipe rail. The robot is manually driven while moving from a rail to the next rail. The drive platform and autonomous operation control system are developed based on IT fusion technology. The pesticide spray system is also developed with nozzles and booms for precision mist spray system. Experimental data of nozzle test is also included.