The transcutaneous energy transmission system (TETS) composed of a Class-E amplifier may operate at a state away from the optimum power transmission due to the load variation. By introducing the feedback-loop technique, the TETS can keep the optimum state with constant output voltage by adjusting the important design parameters, that is, the duty ratio and frequency of the driving signal and the supply voltage. The relations between these adjusted parameters and the load are investigated. The effectiveness of the feedback technique is validated through a design example with a variable load parameter. The experimental results show that the Class-E amplifier in the feedback loop can keep operating at the optimum state under the condition of up to 50 percent variation of the load value.