Unsteady numerical analysis was performed to simulate air-launched missiles from a complete helicopter in hover by using an unstructured overset mesh flow solver coupled with a module of six degree-of-freedom motion of equations. The unsteady computations have been performed to obtain flow fields around the complete helicopter including main rotor, tail rotor, and fuselage equipped with multiple missiles, and six-DOF simulation has been performed to predict the behavior of the air-launched missile. The effects of the launching position and the missile thrust on the trajectory of the missile were investigated as well as the aerodynamic interference of the air-launched missile under the unsteady downwash produced by main rotor.