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Characterization of Antibacterial Activity and Synergistic Effect of Cationic Antibacterial Peptide-resin Conjugates
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  • Characterization of Antibacterial Activity and Synergistic Effect of Cationic Antibacterial Peptide-resin Conjugates
  • Characterization of Antibacterial Activity and Synergistic Effect of Cationic Antibacterial Peptide-resin Conjugates
저자명
Kim. Jeong-Min,Jang. Su-Jung,Yang. Mi-Hwa,Cho. Hyeong-Jin,Lee. Keun-Hyeung
간행물명
Bulletin of the Korean Chemical Society
권/호정보
2011년|32권 11호|pp.3928-3932 (5 pages)
발행정보
대한화학회
파일정보
정기간행물|ENG|
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

We synthesized peptide-resin conjugates (1 and 2) by immobilizing ${eta}$-sheet antibacterial peptide and ${alpha}$ helical antibacterial peptide on PEG-PS resin, respectively. Conjugate 1 showed considerable antibacterial activity in various conditions, whereas conjugate 2 did not exhibit antibacterial activity. The growths of various bacteria were inhibited by conjugate 1 even at lower concentrations than MIC. Conjugate 1 killed bacteria at MIC and had a potent synergistic effect with current antibacterial agents such as vancomycin and tetracycline, respectively. Overall results indicate that polymer surface modification using antibacterial ${eta}$ sheet peptide is a powerful way to prevent microbial contamination on polymer surfaces.