This Paper proposed the prediction method of fuel consumption from vehicle diagnosis informations through OBD-II Interface. We assumed mass air flow (MAF), shor-term fuel trim (STFT), and long-term fuel trim (LTFT) had a relationship with fuel consumption. We got the output as fuel-consumption from MAF, STFT, and LTFT as input variables. We had modelling as combustion reaction equation with OBD-II data and fuel consumption data supported by automotive company in real. In order to verify the effectiveness of proposed method, 5 km real road-test was performed. The results showed that the proposed method can estimate precisely the fuel consumption from vehicle data.