This study was to examine factors related to depression of female labor workers. In order to identify health promotion strategies and intervention program to reduce depression of female labor workers. The participants were 176 female workers of manufacturing industries. Data were collected using a structured questionnaire that consisted of personal characteristics, duty related, work related characteristics and depression. Using a SPSS/WIN 17.0 Program, descriptive statistics, $x^2$-test, ANOVA and Stepwise Multiple Regression procedures were employed. As follows on the results; In Correlation analysis, work intensity, work concentration, vibration, work difficulty and job stress were positively correlated with depression. In multiple Regression, work intensity and work difficulty were significantly explained by depression. Given the findings, Do nevertheless support the need to develop effective depression intervention programs to reduce factors which work related condition and depression.