Mine countermeasure missions(MCMs) may induce the loss of human and ship because of the covert of mine. In recent years, unmanned underwater vehicles(UUVs) have emerged as viable technical solution for conductimg underwater search, surveillance, and clearance operations in support of mine countermeasure missions because of her autonomy and long time endurance capability. This paper introduces a technical approach to mine countermeasure mission effectiveness analysis and presents some simulation-based analysis results for engineering of the UUV system definition which could be support analysis of alternatives for system definition and design.