Large eddy simulation(LES) of fully developed turbulent pipe flow has been performed to investigate the effect of Reynolds number on the flow field at $Re_{ au}$=180, 395, 590 based on friction velocity and pipe radius. A dynamic subgrid-scale model for the turbulent subgrid-scale stresses was employed to close the governing equations. The mean flow properties, mean velocity profiles and turbulent intensities obtained from the present LES are in good agreement with the previous numerical and experimental results currently available. The Reynolds number effects were observed in the higher-order statistics(Skewness and Flatness factor). Furthermore, the budgets of the Reynolds stresses and turbulent kinetic energy were computed and analyzed to elucidate the effect of Reynolds number on the turbulent structures.