In this paper, the problem on periodic solutions of the bidirectional associative memory neural networks with both periodic coefficients and periodic time-varying delays is discussed. By using degree theory, inequality technique and Lyapunov functional, we establish the existence, uniqueness, and global asymptotic stability of a periodic solution. The obtained results of stability are less restrictive than previously known criteria, and the hypotheses for the boundedness and monotonicity on the activation functions are removed.