This study conducted a secondary analysis by using original data of <The Third Korea National Health and Nutrition Examination Survey, 2005> performed by Korea Institute for Health and Social Affairs to determine factors affecting health-related quality of life in the elderly. The results were as follows. For medical health condition, it became longer in endocrine diseases and cardiovascular diseases. In the case of functional health condition, subjects with musculoskeletal diseases showed higher functional health condition. Subjective health condition, while it became worse in digestive diseases and musculoskeletal diseases in the order, it recorded the best score when subjects did not have any musculoskeletal disease. Quality of life, while it became lower in endocrine diseases in the order, it was the highest when subjects did not have any musculoskeletal disease. Thus, increase of subjective health status for the elderly is important in the future.