In this study, performance of R410A(50%R32/50%R125) and HFC32/HFC125 mixture is measured to examine the effect of composition shift of R410A used for various air-conditioners and heat pumps. The composition of HFC32/HFC125 mixture varies from the reference composition of R410A ${pm}10%$ with 5% interval. Tests carried out in a heat pump bench tester at the evaporation and condensation temperatures of $7/45^{circ}C$ and $-7/41^{circ}C$ for summer and winter conditions, respectively. Test results show that both the coefficient of performance (COP) and compressor power of the HFC32/HFC125 mixture have the maximum difference of 2.0% as compared to those of R410A. Compressor discharge temperatures of HFC32/HFC125 mixture are increased up to $6.7^{circ}C$ as compared to that of R410A. The amount of charge for HFC32/HFC125 mixture vary within 5.6% as compared to that of R410A. Overall, performance of R410A is not appreciably affected by the composition shift of ${pm}10%$ of R32 under both air-conditioning and heat pumping conditions.