As sea state harsher in the ocean space, more large motion and wave loads occurs on ships hull by non-linear phenomena. To consider nonlinear effect on ships hull in the structural design verification, the direct calculation method with numerical approach is used rather than rule values for the reliable accuracy. In this paper, the non-linear wave loads analysis in time domain is performed by using a Rankine Panel Method together with numerical schemes. Linear calculations have been carried out based on DNV CSA-2 notation to generate the motion responses and wave loads of large ships. By short and long term analysis, the design wave amplitudes are selected for the nonlinear analysis. The maximum wave induced bending moment in hogging and sagging conditions are calculated in the nonlinear analysis. Also, the green water effect on the wave induced vertical bending moment was investigated. The results show the vertical bending moments are more influenced by green water in sagging condition than in hogging condition due to green water loading.