This study analyzed the influence of firing biogas on the performance and operation of a gas turbine combined heat and power (CHP) system. A reference CHP system designed with natural gas fuel was set up and off-design simulation was made to investigate the impact of firing biogas in the system. Changes in critical operating parameters such as compressor surge margin and turbine blade temperature caused by firing biogas were examined, and a couple of operating schemes to mitigate their changes were simulated. Part load operation of the biogas-fired system was compared with that of natural-gas fired system, and it was found that as long as the two system produce the same electric power output, they exhibit nearly the same heat recovery.