This paper describes the shape optimization of a blower impeller used for a refuse collection system. Two design variables, which are used to define the blade angles of an impeller, are introduced to increase the blower performance. A blower efficiency is selected as an object function, and the shape optimization of the blade angles is performed by a response surface method (RSM). Three-dimensional Navier-Stokes equations are introduced to analyze the internal flow of the blower and to find the value of object function for the training data. Relatively good agreement between experimental measurements and numerical simulation is obtained in the present study. Throughout the shape optimization, blower efficiency for the optimal blade angles is successfully increased up to 3.6% compared with that of reference at the design flow rate. Detailed flow field inside the turbo blower is also analyzed and discussed.