An optimal design method for a structural control system considering load variations due to their uncertain characteristics is studied in this paper. The conventional design problem for a control system generally deals with the optimization problem of a structural control system and interaction between the structure and the control device. This study deals with the optimization problem of a load-structure-control system and the more complicated interactions with each other. The problem of finding the load that maximizes the structural responses and the structural control system that minimizes the responses simultaneously is formulated as the min-max problem. In order to effectively obtain the optimal design variables, a co-evolutionary algorithm is adopted and, as a result, an optimal design procedure for the linear structural control system with uncertain dynamic characteristics is proposed. The example design and simulated results of an earthquake excited structure validates the proposed method.