The dynamic mechanical behavior of silicone rubber reinforced with multi-walled carbon nanotubes (MWCNTs) has been investigated in this study. The MWCNT-reinforced nanocomposites are tested in compression mode through dynamic mechanical analysis (DMA). Multiple effects including MWCNT loading, testing frequency, dynamic strain amplitude, and pre-strain level are taken into consideration. Results show that, by adding 5 wt% of MWCNTs, the dynamic stiffness and damping coefficient of the silicone rubber are significantly enhanced. It is further observed that the dynamic mechanical properties of the nanocomposites are sensitive to dynamic strain amplitude but only slightly affected by pre-strains.