Based on the ANSYS, an approach of full-mode aerodynamic flutter analysis for long-span suspension bridges has been presented in this paper, in which the nonlinearities of structure, aerostatic and aerodynamic force due to the deformation under the static wind loading are fully considered. Aerostatic analysis is conducted to predict the equilibrium position of a bridge structure in the beginning, and then flutter analysis of such a deformed bridge structure is performed. A corresponding computer program is developed and used to predict the critical flutter wind velocity and the corresponding flutter frequency of a long-span suspension bridge with double main span. A time-domain analysis of the bridge is also carried out to verify the frequency-domain computational results and the effectiveness of the approach proposed in this paper. Then, the nonlinear effects on aerodynamic behaviors due to aerostatic action are discussed in detail. Finally, the results are compared with those of traditional suspension bridges with single main span. The results show that the aerostatic action has an important influence on the flutter stability of long-span suspension bridges. As for a suspension bridge with double main spans, the flutter mode is the first anti-symmetrical torsional vibration mode, which is also the first torsional vibration mode in natural mode list. Furthermore, a double main-span suspension bridge is better in structural dynamic and aerodynamic performances than a corresponding single main-span structure with the same bridging capacity.