전통주의 간독성 유무를 확인하기 위하여 Rhizopus stolonifier NO. 17 누룩과 Saccharomyces cerevisiae, 증자미 등을 이용하여 전통주를 제조한 후 농축물을 제조한 다음 실험동물 쥐에 경구투여 하여 몸무게 변화와 혈청 생화학적 검사 등을 실시하였다. 제조한 전통주 농축물은 실험동물 쥐의 몸무게에 영향을 주지 않았고 total protein, total cholesterol, albumin 함량과 GOT, GPT 등을 전통주 농축물을 처리한 시험구와 무처리 대조구의 암컷 쥐와 수컷 쥐 결과와 비교 하였을때 모두에서 약간 상승하거나 감소하였을 뿐 큰 차이가 없었으므로 제조한 전통주는 간 독성이 없는 것으로 추정된다.
To investigate liver toxicity of traditional rice wine, traditional rice wine was prepared by using cooked rice, Rhizopus stolonifier No. 17 nuruk and Saccharomyces cerevisiae. After concentrated the traditional rice wine, it was orally administered into Sprague-Dawley(SD) rats and then changes of its body weight and biochemical parameters of the blood were investigated. All of male and female SD rats did not show any changes in its body weight during two weeks after administering the traditional rice wine concentrates and also biochemical parameters such as aspartate aminotransferase (AST or GOT), alanine aminotransferase (ALT of GOT) and alkaline phosphatase activity were not different compared to control. This results indicated that the traditional rice wine has not any toxicity.
