This paper presents a new method that can solve the integrated problem of combined location routing and inventory problem (CLRIP) efficiently. The CLRIP is used to establish facilities from several candidate depots, to find the optimal set of vehicle routes, and to determine the inventory policy in order to minimize the total system cost. We propose a mathematical model for the CLRIP with budget constrained. Because this model is a nonpolynomial (NP) problem, we propose a endosymbiotic evolutionary algorithm (EEA) which is a kind of symbiotic evolutionary algorithm (SEA). The heuristic method is used to obtaining the initial solutions for the EEA. The experimental results show that EEA perform very well compared to the existing heuristic methods with considering inventory control decisions.