Recently, a number of large-scale photovoltaic(PV) power generation system has been installed all over the world. Thus, in order to improve the system efficiency, the optimal design of the large-scale PV systems has become an important issue. DC cable loss of PV array is one of the design factors related to the system efficiency. This paper introduces the array design method of a 500kW Photovoltaic power plant. Three types of the PV array are suggested. Also, string cables, sub-array cables and array cables are designed within 1% of voltage drop in the line, and the DC cable losses are analyzed. The results of this paper show that the DC cable loss of large-scale PV array can be reduced by adopting a proper sub-array design method.