The structural integrity assessment of APR1400 (Advanced Power Reactor 1400) reactor vessel internals has been being performed referring the US Nuclear Regulatory Commission regulatory guide 1.20 comprehensive vibration assessment program prior to commercial operation. The program is composed of a hydraulic and structural analysis, a vibration measurement, and an inspection. This paper describes the hydraulic and structural analysis on the reactor vessel internals due to hydraulic loads caused by the turbulence of reactor coolant. Three-dimensional models were built for the hydraulic and structural analysis and then hydraulic loads and structural responses were predicted for five analysis cases with CFX and ANSYS respectively. The structural responses show that the APR1400 reactor vessel internals have sufficient structural integrity in comparison with the acceptance criteria.