Evolutionary operation (EVOP) proposed by Box(1957) is a method for continuous monitoring and improvement of a full-scale manufacturing process with the objective of moving the current operating conditions toward the better ones. EVOP in experiments with mixtures consists of screening vital few components and making small changes in the current operating condition by making small increments in the proportion of the screened component. In this paper, how to determine operating conditions in EVOP in experiments with mixtures around the current operating condition is proposed. The proposed methods are illustrated with the simulated data based on the well known flare experimental data described by McLean and Anderson(1966).