Moisture stress is the major constraint to rice production and its stability in rainfed, mainly irrigated, and aerobic environments. Identification of genomic regions conferring tolerance to stress would improve our understanding of the genetics of stress response and result in the development of drought tolerant cultivars. In the present study, quantitative trait loci for drought response related traits and as well as grain yield were identified using a set of 140 recombinant inbred lines derived from a cross between the popular high-yielding variety, IR64 and the landrace, INRC10192. A total of 36 QTL were identified for grain yield and its components under control and stress conditions. Strikingly, a QTL cluster flanked by the markers RM38 and RM331 on chromosome 8 was found to be associated with grain yield, plant height, no. of productive tillers, chaffy grains, and spikelet fertility on secondary rachis and biomass under stress treatment. The genomic regions associated with these QTL under drought stress will be useful for the development of marker-based breeding for drought tolerant, high-yielding varieties suited to drought-prone areas.