기관회원 [로그인]
소속기관에서 받은 아이디, 비밀번호를 입력해 주세요.
개인회원 [로그인]

비회원 구매시 입력하신 핸드폰번호를 입력해 주세요.
본인 인증 후 구매내역을 확인하실 수 있습니다.

회원가입
서지반출
Comparative Study of Telmisartan Tablets Prepared via the Wet Granulation Method and $Pritor^{TM}$ Prepared Using the Spray-drying Method
[STEP1]서지반출 형식 선택
파일형식
@
서지도구
SNS
기타
[STEP2]서지반출 정보 선택
  • 제목
  • URL
돌아가기
확인
취소
  • Comparative Study of Telmisartan Tablets Prepared via the Wet Granulation Method and $Pritor^{TM}$ Prepared Using the Spray-drying Method
  • Comparative Study of Telmisartan Tablets Prepared via the Wet Granulation Method and $Pritor^{TM}$ Prepared Using the Spray-drying Method
저자명
Park. Jun-Sung,Park. Hee-Jun,Cho. Won-Kyung,Cha. Kwang-Ho,Yeon. Won-Ki,Kim. Min-Soo,Kim. Jeong-Soo,Hwang. Sung-Joo
간행물명
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
권/호정보
2011년|34권 3호|pp.463-468 (6 pages)
발행정보
대한약학회
파일정보
정기간행물|ENG|
PDF텍스트
주제분야
기타
이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
서지반출

기타언어초록

The wet granulation method was successfully used to manufacture amorphous telmisartan tablets (CNU) for comparison with the spray-drying method, used for $Pritor^{TM}$. Drug crystallinity in the tablet was characterized using differential scanning calorimetry and powder X-ray diffraction, and pharmaceutical properties of the tablets such as hardness, friability, water absorption, and in vitro dissolution in pH 1.2, 4.0, 6.8 and 7.5 were characterized. Especially with regard to the water absorption feature, the CNU tablets showed better performance by maintaining their original structures and by absorbing less water. Since both $Pritor^{TM}$ and CNU tablets had similar physical properties of crystallinity, hardness, friability, and > 50 $f_2$ value in an in vitro dissolution study, the bioequivalence of CNU tablets should be analyzed in a future in vivo study. Therefore, telmisartan tablets can be produced using a more economical and easier method than that used to produce $Pritor^{TM}$ tablets.