Objectives : The present study was conducted to determine whether Jerksukji-san and Tangnisodok-eum have an effect on treatment of burn. Methods : 24 male rats were randomly divided into 4 groups. Burns were created by scalding on the skin surface. Immediately after being burned, the rats of group 1 were applied with silver sulfadiazine ointment topically on the burn wound. The rats of group 2 were applied with Jerksukji-san ointment topically and administrated Tangnisodok-eum orally. The rats of group 3 were applied with Jerksukji-san ointment topically. The rats of group 4 were cleaned with saline solution. All treatments were applied twice a day. After 3 and 7 days the inflammatory cellularinfiltration and epidermal gap were measured. Data were analyzed by one-way ANOVA and Kruskal-Wallis test. Results : The rats of groups 1 and 2 showed a statistically narrow epithelial gap compared with those of groups 3 and 4 on the third and on seventh days (p<0.05). Group 3 showed a statistically narrow epithelial gap compared with group 4 on the third and seventh days (p<0.05). The decrease of inflammatory cellularinfiltration observed in group 2 was bigger than in the other groups (group 2>1>3>4) on the third and seventh days. Conclusions : These results demonstrate that Tangnisodok-eum and Jerksukji-san ointment are effective to treat burn, and it is necessary for clinical study to better ascertain this method.