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Inhibition of Rat Lense Aldose Reductase by Flavonoids from Dandelions
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  • Inhibition of Rat Lense Aldose Reductase by Flavonoids from Dandelions
  • Inhibition of Rat Lense Aldose Reductase by Flavonoids from Dandelions
저자명
Mok. So-Youn,Lee. Sul-Lim,Kim. Hye-Min,Lee. Jeong-Min,Lee. Dong-Gu,Ahn. Young-Hee,Park. Chun-Geon,Cho. Eun-Ju,Lee. Sang-Hyun
간행물명
Natural product sciences
권/호정보
2011년|17권 2호|pp.130-134 (5 pages)
발행정보
한국생약학회
파일정보
정기간행물|ENG|
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

The purpose of this study was to evaluate the therapeutic potential of naturally occurring aldose reductase (AR) inhibitors isolated from Korean native plants. The MeOH extract and stepwise polarity fractions of dandelions were tested on rat lens AR inhibition in vitro. Of these, the EtOAc fractions from the leaves of dandelions (Traxacum coreanum, T. officinale, and T. ohwianum) exhibited an AR inhibitory activity ($IC_{50}$ values, 2.37, 1.73 and 2.68 ${mu}g/ml$, respectively). A chromatography of the EtOAc fraction from the leaves of T. coreanum led to the further isolation of two flavonoids identified as luteolin and luteolin 7-O-glucopyranoside. These compounds exhibited strong AR inhibitory activity, with $IC_{50}$ values of 0.15 and 1.05 ${mu}M$, respectively. These results suggested that luteolin is a potent AR inhibitor within dandelions and that it could be a useful lead compound in the development of a novel AR inhibitory agent against diabetic complications.