This paper presents the design optimization process of a short fiber-reinforced plastic armrest frame to minimize its weight by replacing the steel frame with a plastic frame. The analysis was carried out with the equivalent mechanical model and design of experiment (DOE) method. Instead of considering the whole structure, it is divided into three simpler regions to reduce the complexity of the problem through examining its structural characteristics and load conditions. The maximum stress and deflection of the regions that carry the normal load are calculated by the analytical mathematical form derived from an equivalent model. The other regions loaded by contact stress are handled by FEM (finite element method), the DOE method, and the RSM (response surface model). To optimize the design variables in both cases, the object functions derived from these calculations are solved with a CAE (computer aided engineering) tool. This method clearly shows the mechanical and mathematical representation of structural optimization and reduces the computing costs. After design optimization, the weight of the optimum plastic-based armrest frame is reduced by about 18% compared to the initial design of a plastic frame and is decreased by 50% in comparison with the steel frame. Some prototypical armrest frames were also made by injection molding and tested. The research results fulfilled all of the design requirements.