Because the FlexRay protocol has more than 70 configuration parameters and these parameters correlate with each other, designing a FlexRay network is a complex and difficult task. In this study, we propose a design framework that optimizes the two main FlexRay network parameters that are highly relevant to the application algorithm. The design process is composed of two steps for optimizing parameters. In the first step, the static slot length is optimized using a frame-packing algorithm. This algorithm binds network signals into static frames based on their periods and signal groups. In the second step, the communication cycle length is optimally designed with frame-scheduling algorithm and worst-case reponse time analysis. Based on the frame-scheduling algorithm, the response times are analyzed. The proposed design framework was applied to a unified chassis control system as a case study, and the analytical results were verified.