During accident, the interlayer of windshield plays an important role in the crash safety of automotive and protection of pedestrian or passenger. The understanding of its energy absorption capability is of fundamental importance. Conventional interlayer material of automotive windshield is made by Polyvinyl butyral (PVB). Recently, a new candidate of high-performance nanoporous energy absorption system (NEAS) has been suggested as a candidate for crashworthiness. For the model problem of pedestrian head impact with windshield, we compare the energy absorption capabilities of PVB and NEAS interlayers, in terms of the contact force, acceleration, velocity, head injury criteria, and energy absorption ratio, among which results obtained from PVB interlayers are validated by literature references. The impact speed is obtained from virtual test field in PC-CRASH, and the impact simulations are carried out using explicit finite element simulations. Both the accident speed and interlayer thickness are varied to explore their effects. The explicit relationships established among the energy absorption capabilities, impact speed, and interlayer material/thickness, are useful for safety evaluation as well as automotive design. It is shown that the NEAS interlayer may absorb more energy than PVB interlayer and it may be a competitive candidate for windshield interlayer.