1. Objectives: This research was proposed to find out how the recognition on Mangeum-syndrome(亡陰證) of Soyangin in Sasang Constitutional Medicine(SCM) evolved from "Donguisusebowon-GabObon(東醫壽世保元甲午本)"(DGO) to "Donguisusebowon-ShinChukbon(東醫壽世保元辛丑本)"(DSC). 2. Methods: We compared "Donguisusebowon-GabObon(東醫壽世保元甲午本)"(DGO) with "Donguisusebowon-ShinChukbon(東醫壽世保元辛丑本)"(DSC) to know how the symptom, mechanism, treatment principle and treatment methods on Mangeum-syndrome(亡陰證) of Soyangin in Sasang Constitutional Medicine(SCM). 3. Results and Conclusions: (1) The way to categorize the Exterior Disease and Interior Disease was different between DSC and DGO. (2) There was only a fundamental mechanism about the Boktongseolsa-syndrome(gastralgia and diarrhea) and no treatment principles and treatment methods about it in DGO. But the Boktongseolsa-syndrome was evolved into Mangeum-syndrome(亡陰證) in DSC with a detailed mechanism and treatment principles of it. (3) The evolution of Mangeum-syndrome(亡陰證) in DSC from Boktongseolsa-syndrome in DGO was attributed to the experience of treatment on Seomeo-syndrome(?語證).