Agricultural and construction equipment are commonly implemented with rectangular tubing in their structural frame designs. A typical joining method to fabricate these frames is by welding and the use of ancillary structural plating at the connections. This aids two continuous members to pass through an intersection point of the frame with some degree of connectivity, but the connections are highly unbalanced as the tubing centroids exhibit asymmetry. Due to the practice of welded continuous member frame intersections in current agricultural equipment designs, a conviction may exist that welded continuous member frames are superior in structural strength over that of structural frame intersections implementing welded non-continuous members where the tubing centroids lie within two planes of symmetry, a connection design that would likely fabricating a more fatigue resistant structural frame. Three types of welded continuous tubing frame intersections currently observed in the designs of agricultural equipment were compared to two non-continuous frame intersection designs. Each design was subjected to the same loading condition and then examined for stress levels using the Finite Element Method to predict fatigue life. Results demonstrated that a lighter weight, non-continuous member frame intersection design was two magnitudes superior in fatigue resistance than some current implemented frame designs when using Stress-Life fatigue prediction methods and empirical fatigue strengths for fillet welds. Stress-Life predictions were also made using theoretical fatigue strength calculations for the fatigue strength at the welds for comparison to the empirical derived weld fatigue strength.