This study presents the results of parametric studies of the P-M interaction diagram of hollow prestressed concrete bridge columns. Among the numerous parameters, this study concentrates on concrete compressive strength, prestressing steel reinforcement ratio, effective prestress, the Ds/Do ratio, and the Di/Do ratio. The strength and ductility of hollow prestressed concrete bridge columns were evaluated through quasistatic tests. The P-M interaction diagrams from the codes were different from that of the results, which were in good agreement with AASHTO-LRFD. Nondimensionalized P-M interaction diagrams were developed to predict the design resistance of hollow prestressed concrete bridge columns.