To improve the total efficiency of centrifugal compressor, it is necessary to reduce the disk friction loss, which is defined as the power loss. In this study, the disk friction loss due to the axial clearance and the surface roughness effect is analyzed and proposed the new empirical equation for the reduction of the disk friction loss. The rotating reference frame technique and the 2-equation k-${omega}$ SST model using commercial CFD code FLUENT is used for the steady-state analysis of the centrifugal compressor impeller. According to CFD results, the disk friction loss of the impeller is more affected by the surface roughness than the change of the axial clearance. For the minimization of the disk friction loss on the centrifugal compressor impeller, the magnitude of the axial clearance should be designed to the same size compare with theoretical boundary layer thickness and the surface roughness should be minimized.