The purpose of this study was to analyze the relationship between leadership life skills, social competence and self-regulation ability of scientifically gifted and regular middle school students. The subjects for this study were 351 middle school students in Busan. The results of this study were as follows: First, scientifically gifted students had higher significant differences in leadership life skills, social competence and self-regulation ability than regular middle school students. Second, there were significant positive correlations between leadership life skills, social competence and self-regulation ability. Third, social competence and self-regulation ability affected leadership life skills. This suggests that social competence and self-regulation ability are important variables to develop and improve leadership life skills of gifted students.