Antioxidant and anti-inflammatory activities of methanolic extract of Clerodendrum cyrtophyllum Turcz (ECT) were investigated in the present study. ECT showed high phenolic content ($223{mu}g{cdot}GAE^{-l}$ equivalent) and strong 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging ($IC_{50}=52.74{mu}g{cdot}mL^{-l}$) and reduced power ability. Furthermore, ECT exhibited significant protective ability in $H_2O_2/Fe^{3+}$/ascorbic acid-induced DNA and protein damage. Moreover, ECT inhibited NO production by 47.15% at $0.8mg{cdot}mL^{-l}$ in lipopolysaccharides-stimulated RAW264.7 macrophages. Semi-quantitative reverse transcription polymerase chain reaction (RT-PCR) analysis showed that the expression of iNOS and COX-2 in RAW264.7 cells was down-regulated after treatment with increasing concentration of ECT. In conclusion, ECT has shown potent antioxidant and anti-inflammatory activities could be considered as a source of health promoting antioxidant and complementary medicinal supplement.