- 약물독성시험에서 실험설계가 MTD의 결정에 미치는 영향
- ㆍ 저자명
- 이윤동,이은경,Lee. Yoon-Dong,Lee. Eun-Kyung
- ㆍ 간행물명
- 品質經營學會誌
- ㆍ 권/호정보
- 2011년|39권 2호|pp.329-336 (8 pages)
- ㆍ 발행정보
- 한국품질경영학회
- ㆍ 파일정보
- 정기간행물| PDF텍스트
- ㆍ 주제분야
- 기타
The purpose of Phase I clinical trial is to identify the maximum tolerated dose with specific toxicity rate. The standard TER design does not guarantee the pre-specified toxicity rate. It depends on the dose-toxicity curves. Therefore it is necessary to check the expected toxicity rate of various dose-toxicity curves before we conduct clinical trials. We developed TERAplusB library to help this situation, especially in cancer research. This package will help design the cancer clinical trial. We can compare the expected toxicity rates, the expected number of patients, and the expected times calculated with various dose-toxicity curves. This process will help find the best clinical trial design of the proposed drug.