In this paper, a current stimulator circuit with adaptive supply regulator for retinal prosthesis is proposed. In current stimulation systems, the stimulating circuits with wide voltage swing range are needed due to the high impedance of the retina cell and microelectrodes. Thus, previous researches adopt the high voltage architecture to obtain the enough operating range. The high voltage architecture, however, could increase the power consumption and can damage the retina cells. The proposed circuit provides the adaptively regulated supply voltage by measuring the difference between desired stimulation current and the actual stimulation current. The proposed circuit can achieve the extended range of the allowable cell impedance, improved accuracy of the stimulation current, and higher biosafety.