Objectives : We report a case of Erythema Nodosum on lower extremities which was by acupuncture and herbal medicine treatment. Methods : We treated a female patient who has erythema nodosom, edema at lower extremities and arthralgia with acupuncture and Moktongdaean-tang.. To evaluate the results of this treatment, we observed shape and number of Erythema Nodosum. We measured circumference of left ankle. We used visual analogue scale(VAS) of arthralgia. Results : Erythema Nodosum on lower extremities, Edema of both ankle were subsided. Arthralgia was gradually disappered. Conclusions : Acupuncture and Moktongdaean-tang have improved the signs and symptoms of Erythema Nodosum case. It is concluded that acupuncture, herbal medicine treatment is considerably effective on Erythema Nodosum.