Although there have been many endeavors aimed at the standardization and globalization of Korean medicine over a long period of time, the access to information on Oriental medical classics has been relatively poor due to the lack of appropriate translation methodology and standard terminology. In order to overcome existing barriers, continuous effort towards precise translation adopting a standard terminology should be maintained. As a part of this procedure, we planned to publish a part of "Classic of difficult issues(難經)" in three sections, and the first two studies have already been published. Based on the methodology and approaches of previous studies, this third study aims to translate parts of "Classic of difficult issues(難經)" into English, beginning with "The Sixteenth Question", and adopting "WHO-IST" terminology. The outcomes of this study are presented as follows: First, based on the result of existing translation studies and the outcome of "WHO-IST", English translation of "Classic of difficult issues(難經)" from "the Sixteenth Question" to "The Twenty-second Question" is offered, hoping to set a model of translation study which can be communicated universally. Second, in order to pave the way for future success in establishing translation studies, it is natural to verify the effectiveness and practicality of standard terminologies including the outcome of "WHO-IST". Continuous translation studies will be required in order to obtain constant feedback and adopt more suitable guidelines during the standardization process. Taking this into consideration, further translation studies of Oriental medical classics including "Classic of difficult issues(難經)" should be continued.